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(Left ) Cone photoreceptors (red and green) and rods (blue). (Middle)
In a detached retina, cones have nearly disappeared. (Right) Cones
preserved by treatment with an increased oxygen environment.
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Vision Research on Behalf of
His Dad
Edward Barawid’s purposeful path to undergraduate
research led from his childhood home in Poway, California, to his
UCSB dorm, and on to the campus laboratory of one of the world’s
most renowned vision researchers. When Edward went off to UCSB to
major in biopsychology, his roommate Shine Ling,
who was majoring in biology at UCSB’s College of Creative Studies,
had good advice. (A go-getter in his own right, Shine's undergraduate
research with a marine biologist has contributed to scientific knowledge.) “When
you come to a major research university like UCSB, you have to take
advantage of its resources,” Shine told his friend. “The
professors are top-notch, so find a research position with someone
whose work interests you.” Because Edward’s father suffers
from retinitis pigmentosa, a rare, hereditary eye disease that often
leads to blindness, Edward said he wanted to learn more about vision
research. Shine suggested he contact neurobiologist Steven
Fisher, in the Department of Molecular, Cellular, and Developmental
Biology and the Neuroscience Research Institute, who investigates
the ultrastructure of vertebrate retina.
Learning From One of the World's Great Scientists
When Edward, then a sophomore, sent an e-mail note to Professor Fisher,
the scientist invited him to join a neurobiology seminar and
begin
to get a
sense of
the material. “One
of my professors made a presentation there,” Edward says, “and I
was able to comprehend parts of it!” Afterward, he introduced himself to
Professor Fisher and asked if he could work in his lab, but was told that before
he did hands-on research, he should read a number of recommended journal articles.
Then the neurobiologist met with Edward three or four times a month to discuss
the material and answer Edward’s questions. “It made a difference, “ Edward
says now. “He explained the technical terms, clarified information, and
sometimes drew pictures to illustrate. The experience built my confidence.”
Edward worked for three years in the Fisher lab, doing a quantitative analysis
of cone photoreceptors in detached and reattached retinas. (The images above
appeared in the article “The Ability of Hyperoxia to Limit the Effects
of Experimental Detachment in Cone-Dominated Retina,” by T. Sakai, G.P.
Lewis, K.A. Linberg, and S.K. Fisher, published in the journal Investigative
Ophthalmology and Visual Science, 2001; 13: 3264–3723.) He also sat in
on
the lab team’s weekly meetings, where researchers presented their findings. “It
was a great experience!” says Edward, who in his senior year spoke about
his undergraduate research on a faculty/student panel during the campus’ Discovery
Days orientation for new students. “The skills I’ve learned—from
antibody staining to fluorescent microscopy to patience—will help me when
I go on to medical school.”
Edward spent the last quarter of his senior year studying
in Hong Kong. He sidestepped the SARS epidemic there, and is now back home near
San
Diego—preparing for a career in ophthalmology. |
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